Prolia can also increase the risk of stillbirth, as well as infant death following birth. Instead, your doctor may recommend that you exercise more, or that you add more calcium and vitamin D to your diet. And after about 1 month following your dose, Prolia is working at its maximum level to reduce bone loss and help increase your bone density. Prolia works by stopping the action of cells (called osteoclasts) that break down your bone. By blocking these cells from working, Prolia causes an increase in your bone density and strength.
- A healthcare provider will give you this injection in a hospital or clinic.
- The following lists contain some of the key side effects that may occur while taking Prolia.
- If you develop serious side effects while using Prolia, call your doctor right away.
- By blocking these cells from working, Prolia causes an increase in your bone density and strength.
- Bisphosphonates are available in various forms called Alendronate (Fosamax), Risedronate (Actonel), Ibandronate (Boniva), and the intravenous form Zoledronic acid (Reclast).
Or they may recommend a prescription medication, such as Prolia. Prolia is approved to treat osteoporosis in females who’ve gone through menopause. Osteoporosis that happens after menopause is due to the decrease in your body’s estrogen level that occurs with menopause.
The primary efficacy variable was percent change in lumbar spine BMD from baseline to 1-year. Secondary efficacy variables included percent change in total hip, and femoral neck BMD from baseline to 1-year. A population pharmacokinetic analysis was performed to evaluate the effects of demographic characteristics. This analysis showed no notable differences in pharmacokinetics with age (in postmenopausal women), race, or body weight (36 to 140 kg). Advise females of reproductive potential to use effective contraception during therapy, and for at least 5 months after the last dose of Prolia. Advise patients that if a dose of Prolia is missed, the injection should be administered as soon as convenient.
In postmarketing experience, severe and occasionally incapacitating bone, joint, and/or muscle pain has been reported in patients taking Prolia [see ADVERSE REACTIONS]. The time to onset of symptoms varied from one day to several months after starting Prolia. Consider discontinuing use if severe symptoms develop [see PATIENT INFORMATION]. New vertebral fractures occurred as early as 7 months (on average 19 months) after the last dose of Prolia. Prior vertebral fracture was a predictor of multiple vertebral fractures after Prolia discontinuation. Evaluate an individual’s benefit-risk before initiating treatment with Prolia.
Risk of bone fractures after skipping or stopping treatment
In fact, before Prolia was approved by the Food and Drug Administration (FDA), the drug’s safety was tested. For all of Prolia’s approved uses, the drug was shown to be a safe medication. In fact, within only a few days after your Prolia dose, your body decreases its breakdown of bone. They’re given in your doctor’s office, so be sure to schedule your appointments ahead of time.
What are Prolia’s side effects?
Evenity (romosozumab-aqqg) and Prolia (denosumab) are brand-name solutions. They’re both prescribed for osteoporosis in certain people. alcohol definition formula and facts Both drugs are given as subcutaneous injections by healthcare professionals. This medicine may cause jaw bone problems (osteonecrosis).
Aromatase inhibitors are a class of drugs that are often used for adjuvant treatment of breast cancer. This class of drugs includes medications such as anastrozole (Arimidex) and exemestane (Aromasin). In males, osteoporosis can be caused by decreased production of hormones, such as testosterone. Prolia comes as a solution inside prefilled syringes that each hold 60 mg of the drug. Prolia is given as an injection under your skin (called a subcutaneous injection). The drug can be injected into your upper thigh, upper arm, or abdomen (belly).
Patients on concomitant immunosuppressant agents or with impaired immune systems may be at increased risk for serious infections. Consider the benefit-risk profile in such patients before treating with Prolia. In patients who develop serious infections while on Prolia, prescribers should assess the need for selling prescription drugs illegally continued Prolia therapy. Decreases in serum calcium levels to less than 8.5 mg/dL at any visit were reported in 0.4% women in the placebo group and 1.7% women in the Prolia group. The nadir in serum calcium level occurs at approximately day 10 after Prolia dosing in subjects with normal renal function.
What is Prolia injection?
With jaw necrosis, your teeth may become loose and need to be removed. The risk of jaw necrosis may be increased the longer that you take Prolia. Call your doctor right away if you have a severe allergic reaction to Prolia. But call 911 if your symptoms feel life threatening, or if you think you’re having a medical emergency.
You can also talk with your doctor about the risks of receiving this drug during pregnancy. Before starting Prolia treatment, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you take.
What is the typical dosage of Prolia?
When stopping Prolia, bone turnover increases to above-usual values 9 months after the last dose. “Bone turnover” refers to how quickly your bones replace old bone tissue with new bone tissue. Bone turnover takes about 24 months after the last dose of Prolia to return to a typical rate. Your doctor may recommend treatment for your pain, depending on the severity. They may also recommend that you stop using Prolia and try a different medication for your condition.
Here’s some detail on some of the side effects this drug may or may not cause. It’s not known if Prolia is safe or effective for use in children. A special MedGuide will be given to you before each treatment. RxList does not provide medical advice, diagnosis or treatment. Keep a list of medicines with you to show to your doctor or pharmacist when you get a new medicine.
A bisphosphonate drug holiday allows time for the medicine to be removed from the bone and reestablishes the normal bone remodeling cycle. That can lead to more bone breakdown and less bone building. The result is porous, fragile bones known as osteoporosis. But research has led to treatments that can target specific parts of the remodeling process and help restore balance. For details about how these drugs performed in clinical trials, see the prescribing information for Evenity and Prolia.
